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Antibiotic therapy

In the treatment of lobar pneumonia, the leading role is played by antibiotic therapy, which must be started immediately, without waiting for the results of sputum bacteriosis, using the empirical method, taking into account the pathogen resistance to the most used drugs and Buy augmentin tablets. In community-acquired lobar pneumonia, aminopenicillins (ampicillin, ticarcillin), fluoroquinolones of the third generation (ciprofloxacin, ofloxacin) are used, sometimes with severe disease and penicillin intolerance - macrolides and cephalosporins of III - IV generation.

In hospital lobar pneumonia, penicillins, cephalosporins, fluoroquinolones, carbapenems, aminoglycosides (sometimes in combination with each other or with the replacement of one with the other) are included in the treatment regimen. The duration of antibiotic therapy depends on the severity and nature of the course of lobar pneumonia, the adequacy and timeliness of the treatment, the rate of normalization of the patient's condition, the dynamics of laboratory, radiological parameters and can range from 7-10 to 14-21 days.

Tablets

In tablet form, clavulanate is used together with amoxicillin. This dosage form is most conveniently given to adults, since the patient’s commitment to treatment is higher, the more convenient and less frequent it is to take the medicine. Dosage - 125 mg of clavulanate in combination with an antibiotic.

In tablet form, clavulanate is used with amoxicillin.

pharmachologic effect

The combined preparation of amoxicillin and clavulanic acid, a beta-lactamase inhibitor. http://www.goodrx.com/augmentin It acts bactericidal, inhibits the synthesis of the bacterial wall.

Active against:

- aerobic gram-positive bacteria (including strains producing beta-lactamases): Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Coryppacterium, Monorybacteris;

- anaerobic gram-positive bacteria: Clostridium spp., Peptococcus spp., Peptostreptococcus spp .;

- aerobic gram-negative bacteria (including strains producing beta-lactamases): Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella spp., Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginaliserissa neerisseris neisseris neisserisseneris neisserinis neisserissenissa neerissenissa neerissenissa catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Yersinia multocida (formerly Pasteurella), Campylobacter jejuni;

- anaerobic gram-negative bacteria (including strains producing beta-lactamases): Bacteroides spp., including Bacteroides fragilis.

Clavulanic acid suppresses type II, III, IV and V types of beta-lactamases, inactive against type I beta-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.